Interoperability of COVID-19 Clinical Phenotype Data with Host and Viral Genetics Data

The outbreak of the COVID-19 epidemic has focused enormous attention on genetics viral infection and related disease. Since beginning pandemic, we collection integration SARS-CoV-2 databases, which contain information structure virus its ability to spread, mutate, evolve; data are made available from several open-source databases. In past, gathered experience human genomics by building models integrated databases genomic datasets (representing, e.g., mutations, gene expression profiles, epigenetic signals). We also coordinated development a dictionary describing clinical phenotype COVID19 disease, in context very large consortium. main objective this paper is describe content process organization. argue that—in disease—interoperability between three domains genomics, phenotype, host essential for empowering important analysis processes results. call actions that could be performed link these data.